The following is a comprehensive ranking of the 100 largest nonprofit organizations in the United States by annual revenue, based on publicly available IRS filings and data from CauseIQ.com. These organizations collectively generate hundreds of billions of dollars in revenue annually, spanning sectors from healthcare and education to disaster relief and the arts.
This list includes donor-advised funds, private foundations, research institutions, hospitals, and well-known charities. Whether you’re a nonprofit professional, donor, researcher, or journalist, this resource offers a window into the scale and diversity of America’s largest tax-exempt organizations. Looking for the top nonprofit foundations that are actually giving out grant money? Here’s your list.
📊 Methodology: Organizations are ranked by total annual revenue as reported in their most recent IRS Form 990 filings. Revenue figures include contributions, grants, program service revenue, and investment income. Data is sourced from CauseIQ, which aggregates IRS filings. Some figures may reflect fiscal years ending in different months.
Annual Revenue
Annual Revenue
3. Bill & Melinda Gates Foundation
Seattle, WA
Annual Revenue
4. Battelle Memorial Institute
Columbus, OH
Annual Revenue
5. The Global Fund
Sweden · Q12: International, Foreign Affairs and National Security Fund Raising and Fund Distribution
Annual Revenue
6. Schwab Charitable Fund
San Francisco, CA · T30: Public Foundations
Annual Revenue
7. National Philanthropic Trust
Jenkintown, PA · T30: Public Foundations
Annual Revenue
8. Silicon Valley Community Foundation
Mountain View, CA · T31: Community Foundations
Annual Revenue
9. Mother Cabrini Health Foundation
New York, NY · T20: Private Foundations
Annual Revenue
10. Feeding America
Chicago, IL · K31: Food Banks, Food Pantries
Annual Revenue
11. Knight Foundation Attn Lisa Mckillips
Beaverton, OR · T20: Private Foundations
Annual Revenue
12. American National Red Cross
Washington, DC · M20: Disaster Preparedness and Relief Service
Annual Revenue
13. Chan Zuckerberg Foundation
Palo Alto, CA · T20: Private Foundations
Annual Revenue
14. Global Health Solutions
Decatur, GA · Q33: International Relief
Annual Revenue
15. Educational Testing Service
Princeton, NJ · B90: Educational Services
Annual Revenue
16. Vanguard Charitable Endowment Program
Malvern, PA · T30: Public Foundations
Annual Revenue
17. International Committee of the Red Cross
Switzerland · Q33: International Relief
Annual Revenue
18. Dana-Farber Cancer Institute
Boston, MA · G30: Cancer
Annual Revenue
19. Johnson and Johnson Patient Assistance Foundation
New Brunswick, NJ · E83: Health Care Financing
Annual Revenue
20. Mitre
Mclean, VA · U30: Physical Sciences, Earth Sciences Research, Services
Annual Revenue
21. National Christian Charitable Foundation
Alpharetta, GA · T30: Public Foundations
Annual Revenue
22. Sunderland Foundation
Leawood, KS · T20: Private Foundations
Annual Revenue
23. Howard Hughes Medical Institute
Chevy Chase, MD · H00: Medical Research: General
Annual Revenue
24. VNS Choice
New York, NY · E92: Home Health Care
Annual Revenue
25. Smithsonian Institution
Washington, DC · A51: Art Museums
Annual Revenue
26. Novartis Patient Assistance Foundation
East Hanover, NJ · E83: Health Care Financing
Annual Revenue
27. HCR Manorcare
Toledo, OH · E91: Nursing, Convalescent Facilities
Annual Revenue
28. Goldman Sachs Philanthropy Fund
New York, NY · T30: Public Foundations
Annual Revenue
29. Aids Healthcare Foundation
Los Angeles, CA · G81: HIV / AIDS
Annual Revenue
30. Direct Relief
Santa Barbara, CA · M12: Public Safety, Disaster Preparedness and Relief Fund Raising and Fund Distribution
Annual Revenue
31. Merck Patient Assistance Program
Kenilworth, NJ · E83: Health Care Financing
Annual Revenue
32. Research Foundation for the State University of New York
Albany, NY · U40: Engineering and Technology Research, Services
Annual Revenue
33. Advanced Technology International
Summerville, SC · U40: Engineering and Technology Research, Services
Annual Revenue
34. Nature Conservancy
Arlington, VA · C34: Land Resources Conservation
Annual Revenue
35. Amgen Safety Net Foundation
Thousand Oaks, CA · E83: Health Care Financing
Annual Revenue
36. Paulson Family Foundation
New York, NY · T20: Private Foundations
Annual Revenue
37. Pfizer Patient Assistance Foundation
New York, NY · E83: Health Care Financing
Annual Revenue
38. Bristol-Myers Squibb Patient Assistance Foundation
Lawrenceville, NJ · E83: Health Care Financing
Annual Revenue
39. Walton Family Foundation
Bentonville, AR · T20: Private Foundations
Annual Revenue
40. The College Board
New York, NY · B90: Educational Services
Annual Revenue
41. Milton Hershey School
Hershey, PA · B24: Elementary School
Annual Revenue
42. National Collegiate Athletic Association
Indianapolis, IN · N60: Amateur Sports Clubs, Leagues
Annual Revenue
43. Aerospace Corporation
Los Angeles, CA · U40: Engineering and Technology Research, Services
Annual Revenue
44. Evangelical Lutheran Good Samaritan Society
Sioux Falls, SD · P75: Senior Continuing Care Communities
Annual Revenue
45. AmeriCares Foundation
Stamford, CT · Q33: International Relief
Annual Revenue
46. AbbVie Patient Assistance Foundation
North Chicago, IL · E83: Health Care Financing
Annual Revenue
47. Research Triangle Institute
Research Triangle Park, NC · U02: Science and Technology Management and Technical Assistance
Annual Revenue
48. Manhattan and Bronx Surface Transit Operating Authority
New York, NY · W00: Public Policy, Public Services Institutions: General
Annual Revenue
49. Compassion International Incorporated
Colorado Springs, CO · X00: Religion: General
Annual Revenue
50. Food For The Poor
Coconut Creek, FL · Q12: International, Foreign Affairs and National Security Fundraising and Fund Distribution
Annual Revenue
51. Community Behavioral Health
Philadelphia, PA · F32: Community Mental Health Center
Annual Revenue
52. Open Society Foundations
New York, NY · T20: Private Foundations
Annual Revenue
53. American Heart Association
Dallas, TX · H01: Medical Research Alliances and Advocacy
Annual Revenue
54. Fred Hutch
Seattle, WA · H30: Cancer Research
Annual Revenue
55. Lilly Endowment
Indianapolis, IN · T20: Private Foundations
Annual Revenue
56. Save the Children Federation
Fairfield, CT · Q33: International Relief
Annual Revenue
57. Fhi 360
Durham, NC · Q30: International Development, Relief Services
Annual Revenue
58. Lilly Cares Foundation
Indianapolis, IN · E83: Health Care Financing
Annual Revenue
59. Greater Worcester Community Foundation
Worcester, MA · T31: Community Foundations
Annual Revenue
60. Health Research Incorporated
Menands, NY · H12: Medical Research Fundraising and Fund Distribution
Annual Revenue
61. American Cancer Society
Atlanta, GA · G30: Cancer
Annual Revenue
62. Big Ten Conference
Rosemont, IL · N60: Amateur Sports Clubs, Leagues
Annual Revenue
63. The Ford Foundation
New York, NY · T20: Private Foundations
Annual Revenue
64. Morgan Stanley Global Impact Funding Trust
Indianapolis, IN · T30: Public Foundations
Annual Revenue
65. Queen’s University at Kingston
Canada · B80: Student Services and Organizations of Students
Annual Revenue
66. International Rescue Committee
New York, NY · Q71: International Migration, Refugee Issues
Annual Revenue
67. American Endowment Foundation
Hudson, OH · T31: Community Foundations
Annual Revenue
68. Florida Parent Network
Jacksonville, FL · B82: Scholarships, Student Financial Aid Services
Annual Revenue
69. Gavi the Vaccine Alliance
Switzerland · Q33: International Relief
Annual Revenue
70. Samaritan’s Purse
Boone, NC · X00: Religion: General
Annual Revenue
71. The Chicago Community Trust
Chicago, IL · T31: Community Foundations
Annual Revenue
72. Walter Scott Family Foundation
Omaha, NE · T20: Private Foundations
Annual Revenue
73. Foundation for the Carolinas
Charlotte, NC · T31: Community Foundations
Annual Revenue
74. Plan International
New York, NY · Q33: International Relief
Annual Revenue
75. Southeastern Conference
Birmingham, AL · N60: Amateur Sports Clubs, Leagues
Annual Revenue
76. Biomedical Research Foundation of Northwest Louisiana
Shreveport, LA · H90: Medical Specialty Research
Annual Revenue
77. Genentech Access To Care Foundation
S San Fran, CA · T20: Private Foundations
Annual Revenue
78. Ulta Beauty Charitable Foundation
Bolingbrook, IL · H30: Cancer Research
Annual Revenue
79. J Paul Getty Trust
Los Angeles, CA · T20: Private Foundations
Annual Revenue
80. Riverspring Health Plans
Bronx, NY · E92: Home Health Care
Annual Revenue
81. Inclusa
Stevens Point, WI · P82: Developmentally Disabled Centers and Services
Annual Revenue
82. Turning Point Foundation
Bowie, MD · B29: Charter Schools
Annual Revenue
83. The Schmidt Family Foundation
Palo Alto, CA · T20: Private Foundations
Annual Revenue
84. Koum Family Foundation
Menlo Park, CA · T20: Private Foundations
Annual Revenue
85. William and Flora Hewlett Foundation
Menlo Park, CA · T20: Private Foundations
Annual Revenue
86. Bank of America Charitable Gift Fund
Providence, RI · T30: Public Foundations
Annual Revenue
87. Draper Laboratory
Cambridge, MA · U40: Engineering and Technology Research, Services
Annual Revenue
88. Cooperative for Assistance and Relief EVERYWHERE
Atlanta, GA · Q33: International Relief
Annual Revenue
89. American Chemical Society
Washington, DC · S41: Promotion of Business
Annual Revenue
90. Southwest Research Institute
San Antonio, TX · U40: Engineering and Technology Research, Services
Annual Revenue
91. Navigate Affordable Housing Partners
Birmingham, AL · L21: Public Housing Facilities
Annual Revenue
92. Population Services International
Washington, DC · Q30: International Development, Relief Services
Annual Revenue
93. Beckman Research Institute of the City of Hope
Duarte, CA · H90: Medical Specialty Research
Annual Revenue
94. Sanofi Foundation for North America
Bridgewater, NJ · E83: Health Care Financing
Annual Revenue
95. Quinnipiac University
Hamden, CT · B41: Community College, Jr. College
Annual Revenue
96. Metropolitan Museum of Art
New York, NY · A51: Art Museums
Annual Revenue
97. Map International
Brunswick, GA · Q33: International Relief
Annual Revenue
98. Domel
Livonia, MI · P80: Services to Promote the Independence of Specific Population Groups
Annual Revenue
99. United States Fund for Unicef
New York, NY · Q33: International Relief
Annual Revenue
100. City of Hope
Duarte, CA · H12: Medical Research Fundraising and Fund Distribution
Annual Revenue
Hint: If you are interested in making it to the top of a list like this for nonprofits, the answer might start with how you build your board of directors.